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KMID : 0378019610040090045
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New Medical Journal
1961 Volume.4 No. 9 p.45 ~ p.77
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Experimental Study on the Influence of Various Steroid Substances upon Allergic Changes in the Spleen
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Abstract
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The endocrine effects upon the allergic reaction on different organs have been extensively investigated by a number of authors. The results were variable and sometimes conflicting in that the reactions were specific to each organ.
This investigation deals with a comparative histopathological study of the influence of various steroid substances upon the experimentally induced allergic inflammation with normal horse serum on the adult rabbit spleen. The steroids used were cortisone, cortical steroids produced by ACTI3. stimulation. estrogen -and androgen. These were given in two different doses, large and small (see text).
The results thereby obtained were distinct to each steroid, although these ´substances . were similar in basic. structure.´
Both cortisone and ACTH exerted pronounced inhibitory effects upon induced allergic inflammation of the rabbit spleen and the former showed greater inhibitory effect than the latter. The small doses of cortisone was more effective in suppressing the allergic reaction than the large doses, while reverse was true with ACTH.
Both estrogen and androgen showed significant enhancing effects upon the allergic inflammatory reaction, and the former produced more pronounced enhancing effect than the latter. Both of these were more effective with the large doses than with the small doses.
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KEYWORD
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